We are interested in determining how cells sense stress and starvation signals, integrate the relevant information, and then decide (1) how fast to grow and (2) which pathways to activate to support growth and survival. To address these questions, we use high-throughput genetic, genomic, modelling, live cell imaging, and biochemical approaches.
Some of the key questions we are currently addressing:
-How are different stress and starvation signals transmitted to the Target of Rapamycin Kinase Complex I (TORC1)–the master regulator of cell growth and metabolism in eukaryotes.
-How is the movement of TORC1 into and out of an inactive agglomerate (we discovered and call a TORC1-body) regulated and how does it impact cell growth and function.
-How do the TORC1, cAMP dependent protein kinase (PKA), AMP activated protein kinase (AMPK), and other signaling pathways cooperate to control cell growth, metabolism, stress responses, and developmental programs.
The laboratory is currently recruiting graduate students and postdoctoral fellows. We welcome applications from individuals with a strong background in biochemistry, molecular biology, and/or quantitative methods. If you are interested please contact Andrew Capaldi directly.